[kevin_b_er]

Full paper at https://www.cureus.com/articles/141805-zinc-supplementation-... and not this summary.

Key limitations: They only used 5 papers

> There were limitations to this study. A small number of studies were assessed, only five were chosen for mortality analysis with a total sample size of 1,474 patients, and two were chosen for symptomology with a sample size of 391 patients. The design of the studies chosen limits the conclusions made in this study regarding mortality as three of the studies are retrospective studies and only two are randomized control trials for mortality. Both papers that assessed symptomology were randomized control trials. Between studies, zinc formulations were different, and in some cases, zinc was given in combination with other drugs.

3 of those studies were retrospectives, 2 were randomized studies. One of those randomized studies was halted for "futility" at zinc treatment.

I'm suspicious about the conclusions.

[Spod_Gaju]

There have been more studies since when this came out, which signals the probable importance of zinc in COVID prevalence. Plus they were only looking at mortality so there will always be fewer papers. Does this leave you less suspicious?

These are all studies released in 2024:

https://www.tandfonline.com/doi/abs/10.1080/10408398.2022.21...

https://link.springer.com/article/10.1007/s12011-023-03788-9

https://www.sciencedirect.com/science/article/abs/pii/S00223...

https://www.researchgate.net/profile/Mohammad-Alam-86/public...

https://www.nature.com/articles/s41598-024-53202-0

https://www.frontiersin.org/articles/10.3389/fnut.2024.13855...

https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-02...

https://link.springer.com/article/10.1186/s41043-024-00504-8

https://www.ingentaconnect.com/content/ben/cmc/pre-prints/co...

https://www.sciencedirect.com/science/article/pii/S266614972...

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.8096