[jbandela1]

This actually makes me a bit concerned about long term, general Ozempic use.

This to me at least makes one suspicious that this pathway is very deep in the reward subsystems of the brain, and is not just specific to say appetite and food.

What are the long-term effects of Ozempic use on these pathways? I am not sure we know?

For example, will people who have taken long-term Ozempic be less likely to do startups because their reward seeking behavior is altered?

It will take many years (decades?) before we get a complete picture of all the downstream effects of this.

Now, if someone is morbidly obese, severely diabetic, has heart disease, etc, I think it is pretty obvious that the benefits outweigh the risks. However, if it is used as an "easy" way for weight-control, especially long-term, I think there are still questions.

If you look back at the history of medicines, we do have a history of "wonder drugs" - see for example Heroin or even the COX-2 inhibitors (Vioxx) that later in retrospect had some major caveats.

[rapjr9]

I've wondered about this also. I haven't heard any reporting that mentions whether or not these drugs cause a change in the desire for sex also.

[createaccount99]

Makes me optimistic, sounds like it has potential to be a very effective nootropic, importantly with a lot of research backing it.

[comova]

We also have a history of vaccines and antibiotics, so I don't think we should automatically assume there's some deep risk. These have been on the market for over a decade now and used by tens of millions of people.

[pertymcpert]

We know it's generally safe for diabetic people because that's what it was originally for. No one tested long term for the last decade of other potential psychological effects like altered reward seeking behavior.