[bglazer]

This is actually not totally correct. AAV’s form episomes, which are circular DNA structures that are basically extra chromosomes. The fact that AAV’s don’t randomly insert themselves into DNA makes them safer for clinical uses like this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519600/

[toufka]

And that’s why replies are helpful in these kind of explanations. My over-edits became wrong, and then an hour later, unfixable. bglazer is correct.

AAVs, unlike Lentiviruses, do NOT integrate.

[bglazer]

The reason I know this is I made the same mistake in a comment on a similar story a few weeks ago!