[throwup238]

> So I think there's a relativity of wrong problem that you run into when suggesting it's all just so complex and leaving it at that.

The problem with talking about human variability is that everyone can be equally wrong just due to the natural distribution.

What if a 30% of people have metabolisms that work better with low-fat/high-carbs, 30% high-fat/low-carbs, and 40% are kinda just in the middle and don't care as long as macros are balanced? Depending on how your sample breaks down (or which group has the most lobbying capital when the rules are made), your nutrition guidance can flip flop, especially if the effects are subtle except over the long term. Without the ability to group them a priori, the results will be all over the place and may even be unstable depending on whose thumb is on the scale.

Psychiatry faces this problem but much worse. Tons of drugs do work, we just don't know which ones will work for which people so both the treatment protocol and the clinical trials are a complete mess.