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by hombre_fatal
746 days ago
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Even if you throw out the research that you mention, you'd still have to contend with https://en.wikipedia.org/wiki/Mendelian_randomization which converges with that research and shows that ApoB is an independent causal factor for CVD, like https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611924/ (random google result). And saturated fat increases ApoB. And Mendelian randomization over genes that increase the saturated fat -> cholesterol or ApoB relationship, or cholesterol and ApoB independently, result in more CVD. The evidence and scientific consensus are still against your wishful thinking. Though these days with algorithmic doom-scroll feeds it can feel like there is no consensus. I follow a lot of evidence based nutrition accounts on Twitter yet I still get recommended quacks like Shawn Baker and Nina Teicholz (carnivore diet charlatans) who make the same points you make to story-tell away the inconvenient truth. And I specifically avoid anti-science quackery. So I can imagine what the average person is seeing and why it seems like the science is reversing. |
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Being able to come up with a single plausible mechanism like you posted makes sense in isolation, but not when you consider the bigger systems level picture of a whole organism and chemically complex foods, and the fact that anyone who has taken undergrad biochem could come up with a dozen that are equally plausible and consistent with the literature but in the opposite direction. I’ll mention Chris Masterjohn, not because I agree with him, but because he’s a nutrition guru that is great at coming up with dozens of plausible mechanisms that argue against what you are saying. That type of mechanistic reductionist reasoning is the main reason nutrition advice is so falsely overconfident and mostly nonsense.