[dekhn]

As much as I want to see gene therapy succeed, I think one generation is awfully aspirational. I figured it was a generation away in the late 1990s- then a single person died in a single gene therapy trial and basically the field languished for over a decade.

Gene therapy seems most suited to diseases caused by single-gene mutations where repairing the mutation cures the disease. I think also it will be almost entirely somatic, not germline modification, for societal acceptance. I expect it to continue to be extremely expensive and high-touch.