[nathan_compton]

I still don't see what you are getting at. It is hard to generate good information about the risks and benefits of drugs and doing RTCs is very difficult, for the reasons to which you refer and others. Are you advocating that we just give up on knowing this stuff? That we do large RTCs that have the statistical power to characterize more "context"? I'm having trouble understanding whether your comment just comes down to "getting knowledge is hard and I'm tired of people trying to do it."

[spacetimeuser5]

I am not advocating for anything, just exercising my English and typing skills. But you can try measuring more parameters in every person, integrate various findings from science and plan experiment design more carefully. I have heard about only one startup using AI to facilitate RCTs. A more optimal option is of course suicide, as the more of these RCT researchers will be out of the game, the more newer and more flexible brains will come in.