[drivebyhooting]

Paracetamol is an anticholinergic isn’t it? It’s bad for your brain and its usage is associated with dementia.

[jprival]

> Paracetamol is an anticholinergic isn’t it?

No, per https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/j.15...

Can’t say whether it’s good for your brain otherwise.

[toxik]

Are you really suggesting paracetamol causes dementia?

[jodleif]

Citation needed

[bobmcnamara]

"Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of new-onset dementia in the old population, regardless of genetic risks of dementia."

https://pubmed.ncbi.nlm.nih.gov/37633120/

[stephc_int13]

Paracetamol is the default painkiller for most people, I would suspect that regular use means some kind of inflammation.

I would not find surprising that chronic headache could be correlated with risk of dementia.

[boomlinde]

The study however found no such association between regular ibuprofen use and dementia. Not sure what compels people to go all "I have no idea what the supposed results of the study are but my amateur intuition about it tells me it's wrong".

[crackedbassoon]

That paper is extremely weak. Look at the confidence intervals surrounding the hazard ratios. There is almost no effect for paracetamol and the difference between paracetamol and ibuprofen is negligible. If this is the evidence, I’m not concerned.

[jodleif]

Thanks!