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by sgonz 741 days ago
Has any research been done on what happens when the body is in a state of high glucose and ketones at the same time?
2 comments

Not that I’m aware of but a number of professional cycling teams have been using them for a few years so there may be something in the works.
Ketoacidosis.
You have a source for that? It’s my understanding that ketoacidosis is pretty hard to achieve unless you’re diabetic or some other serious medical condition. It is not the same as ketosis.
Ketoacidosis would be easy to achieve by just taking too many exogenous ketones too quickly. Ketones are acidic, the body doesn't like to have unbalanced blood pH.

It is rare without ketone supplementation, because unless you're fasting, eating a ketogenic diet, or are diabetic, the body doesn't usually have a high concentration of circulating endogenous ketones.

Diabetics can become so insulin resistant that their cells no longer uptake glucose, so they must fall back to burning ketones for energy, even while blood sugar is very elevated and food intake is normal. This is why DKA is so dangerous and (relatively) common.

Nothing about ketoacidosis is limited to diabetics - its just not common in non-diabetics, because how would you get such high concentrations of ketones? ...

I don't think elite cycling teams would be taking these supps if it caused that, do you?
I frankly don’t care what you believe, but I do care about the ability of the general population to understand reasoning and logic. To that end, please understand that what you’re arguing is not a counter-example like you seem to think it is. It’s an argumentum ad populum - you’re saying this must be true because elite cycling teams are doing it. This is not a proof. It’s not even evidence, you’re not even citing something specific enough to call it that.

Again, believe what you want just make sure you understand that you’re not making a sound argument.

You should probably look into the supplements I’m referring to before launching into a diatribe.
You seem to think that would affect my statement. Pay attention to what I’m actually saying. I have no opinion on the supplement. It’s still invalid reasoning regardless of whether the supplement is effective.
The dose makes the poison.
Also, have you heard of Lance Armstrong? Do you think elite cycling teams worry more about health or performance?

It's a sliding scale from no harm to performance benefits to death. Clearly they are intelligent and educated and those teams expend effort to stay to the left of death...

@sgonz That state results in ketoacidosis, which is fatal.