Only because they were compiled against cpython and not pypy right? If pypy had taken off/over, wouldn't it have been the other way around, where you need to do a special compile any time you want to use a C project with cpython rather than using the prebuilt pypy-compatible version?
Right, I just wasn't familiar with it (never heard this name before) and the only association I could think of for this abbreviated name was psyops and cops. Turns out it's actually for postgres which, of course, is a name I very well know. Didn't realize it was a well-known library!
Edit: things seem to have changed since I last looked into compiling a dependency for pypy. https://doc.pypy.org/en/latest/faq.html#do-c-extension-modul... now says they support c-extension modules without modifications
The package you mentioned, some postgres thing apparently, mentions they support pypy 3.9 and 3.10: https://www.psycopg.org/psycopg3/docs/basic/install.html