[DeathArrow]

Metamizole is the only thing that works for me when I have fever. But it seems that I recently developped an allergy to it, which is a bummer. Every single damn time I take metamizole, I develop very itch rashes.

So by taking some substance it seem I became more sensitive to it's side effects, not less.

[aae42]

This article, and your story reminds me of a University of Guelph professors info regarding bee stings.

https://hbrc.ca/bee-stings/

Those most at risk of developing anaphylaxis from bee stings are not those that get some as rarely as the typical population, or as often as experienced and busy beekeepers wearing mediocre protection, it was the hobbyists wearing complete protection that only got stung once or twice a year.

Made me start wearing a little less protection for fear of developing a stronger allergy.

[goda90]

The immune system is so complex. I have to wonder if allergies develop when something else is stressing the immune system and it misidentifies the culprit.

[modeless]

Current research seems to suggest that allergies develop when the immune system doesn't find anything to fight and goes looking for trouble (the hygiene hypothesis). Although that is a long term effect and I think it's likely that what you said is true as well, on a short term basis. There's also a big difference in being exposed to the natural environment with lots of bacteria and viruses and plants that don't cause disease in humans, which is really what the hygiene hypothesis is about, and getting sick with human diseases, which is not actually beneficial in any way (the immunity gained this way is narrow, not broad, it doesn't "train" your immune system to fight anything but the particular strain of whatever you got).

So my best guess is that when you live a life indoors for years without much exposure to natural outdoor bacteria/viruses/plants, and then you encounter a human disease, your immune system goes into overdrive and misidentifies the culprit.

[rvba]

I never found any drug that can actually reduce fever and is available without prescription.