It was a major consideration for Initial D, which is pretty much the definitive car anime. Animating movement in tandem with dynamic camera movement is very difficult (also why shows like Love Live use 3DCGI for dance scenes, and why Disney was using 3D elements in films like Beauty and the Beast) and modeling accurate vehicle physics in hand drawn animation is also difficult. It simply wouldn't have been viable without 3D animation.
I have never seen Bluey but from the software you linked it is clear that it looks 2D because of how inconsistent the character looks at different angles, for example when you rotate the character the mouth changes position, the hands jump from one sprite to another, it's cel shading with a lot of 2D element on top, it works with simple animation but for anime I'm not optimistic.
I've seen 3D animation where the people are still quite fluid and not awful to look at. Not as good as 2D animation but still pretty good and more than watchable.
https://youtube.com/watch?v=YDqKsQu9el4