Personal anecdote: I used to do a decent amount of LSD (~150ug every 4-5 months for ~3 years), until one time I had an extremely bad trip. Ever since that bad trip, I've found that every time I get high (from LSD, mushrooms, or even marijuana) I start having extreme anxiety to the point where I can't enjoy it anymore and am just waiting for it to end. The bad trip was now 8 years ago and to this day I've not had a great experience on any of the above drugs since then.
I consider myself lucky that the anxiety only shows up when on drugs, which is pretty easy to avoid by, y'know, not doing drugs. But clearly something permanently shifted inside my brain.
The inability to experience something I used to enjoy without a near-panic-attack is a bit more of an effect than a conversation might have.
Memories once missing don’t grow back either. The most extreme cases of LSD use have impacted such basic functions as limiting people’s ability to communicate.
Post lobotomy people generally weren’t brain dead, even if diminished. So for extreme cases, yes it’s a solid comparison.
I consider myself lucky that the anxiety only shows up when on drugs, which is pretty easy to avoid by, y'know, not doing drugs. But clearly something permanently shifted inside my brain.
The inability to experience something I used to enjoy without a near-panic-attack is a bit more of an effect than a conversation might have.