[tetromino_]

In my experience, ibuprofen/advil in an unsealed bottle that's over a year past expiration date simply doesn't work well. You may need 2-3 pills of the expired stuff in a situation where 1 pill of unexpired would be sufficient. This makes it in practice hard to pick a dose which is safe but effective.

After enough such annoyances, I have started consistently throwing out expired Ibuprofen.