[slfnflctd]

If these drugs turn out to be significantly more effective for a wide range of addictions than past approaches, that would indeed be a major societal shift.

I wouldn't try any of them right now, but if my insurance covered one for treating alcoholism at some point I'd give it a shot. If it actually worked it would likely significantly improve not only my life experience, but also my productivity and thereby the lives of others I have an impact on. It's a nice thought.

[trogdor]

Have you considered naltrexone?

[slfnflctd]

I appreciate the thoughtful suggestion. I have not actually tried it, but I've read many accounts from other alcoholics trying to quit who have done so (among a couple dozen other approaches), and came to the conclusion that it's not for me right now. If I did give it a chance I would probably have to go with an implant, which I would only do under extreme circumstances.

What it boils down to is that on some level, I often feel death would be preferable to not being able to experience the 'reward' my brain has been long conditioned to expect from my next drink. If there was a lasting way to shift that to something healthier it would be miraculous. Simply taking it away would just drive me to despair. Having attempted suicide in the past, I do everything I can to avoid that situation again, and unfortunately drinking became a big part of this effort.

[hollerith]

In a Youtube video {Leveraging Dopamine, 2023}, neuroscientist Andrew Huberman defines addiction as "a progressive narrowing of the things that bring us pleasure".

I worry that framing the goal as, "a lasting way to shift that to something healthier", will prime you to switch from one addiction to another. I would prefer for you to frame it as diversifying the sources of pleasure in your life and becoming able to take pleasure (and consequent to take interest) in practical things that you currently experience as tedious obstacles that must be endured so that you can get your next drink.