Interesting I see. I'm moving from breadboarding to PCBs because I'm using ICs which are way too small to solder by hand and I've already prototyped with their off-the-shelf dev board versions.
Consider ordering reusable chunks of your circuit as PCBs instead of iterating on entire boards. You can connect the chunks with breadboards or connectors or something.
How small is "too small" here? I'm by no means an expert at soldering but with some patience I can hand solder down to 0603 components, and I know people who can go much smaller than that (right down to the sort of thing where if you sneeze finding the components you just scattered around is like finding a specific grain of sand on the floor). You can get practice boards for next to nothing online if you don't want to risk damaging high value components.