Is it the same people? It seems like the current Supreme Court is very much against decisions like the weird farmer one and likely to roll such things back.
During the Federalist Revolution period of the the 90s, before Scalia got spooked by drug legalization, the court was definitely heading in the direction of reversing Wickard. Perhaps now that the court is willing to reverse big cases like Roe and Chevron (so it seems) it will also be willing to reverse Wickard.