[ynoxinul]

If a normal PC had an ISA bus (like they did 30 years ago), my network card could have been connected to it with just some minor modifications.

[adql]

Funnily enough modern machines have ISA in form of LPC bus used for few of the common peripherals (TPM) that can be used in ISA-compatible mode, and you can get LPC to ISA adapters.

[Cieric]

They do apparently have an spi bus inside the pcie standard. Don't know if it would be possible with that or not though.

[fsckboy]

not being pedantic, just rounding out the record, ISA's follow-on, EISA, had already been around a while and was already sunsetting 30 years ago because PCI had already been invented. VESA also was ending its brief flash of glory.