[tspng]

Keep in mind that the study is conducted with schizophrenic and bipolar disorder patents that are on medications, are overweight and gained weight while on their current medication and ..."with at least one metabolic abnormality, such as insulin resistance, hypertriglyceridemia, dyslipidemia, or impaired glucose tolerance."...

Given this study design, I don't really find the results that surprising.

[zug_zug]

It may seem like armchair common sense to you, but I doubt any medical facility in the entire country would prescribe a ketogenic diet for those patients because there isn't a hard scientific basis to do so. Also going from insulin resistant to schizophrenia/bipolar is a bit of a surprise.

So this is important work. It'll also be interesting to see if it replicates and generalizes.

[heyoni]

There is some evidence out there that links insulin resistance to depression via BDNF depletion, which is also implicated in schizophrenia. BDNF is also thought to be up regulated by exercise.

https://en.wikipedia.org/wiki/Brain-derived_neurotrophic_fac...

[cpncrunch]

And it is completely uncontrolled.