[stared]

I like saying that it is an S4 - set, setting, substance, and soul.

And the substance (as long as it is a tryptamine) is less important, save for personal preferences. (I have heard a lot about LSD for fun and shrooms for insights - for me, there is no such distinction; if anything, LSD, even in lower doses, produces more profound associations, ones that words cannot capture. At higher doses, well, as you said, the distinction becomes mood.)

At the same time, the soul (overall personality, mind, motivations, desires, approach, will, and goals) is crucial.