Hi! Supervision does not run models, but it connects to existing detection and segmentation libraries, allowing you to do more advanced stuff easily. Take a look here to get a high-level overview: https://supervision.roboflow.com/latest/how_to/detect_and_an....
As for Roboflow, you can use the `inference` package to run (among other things) all Roboflow Universe models locally. Take a look at README examples: https://github.com/roboflow/inference.