[Alpha3031]

Biomed is already too complex to simulate fully, which is why simulating is just, not really a thing that is done to find new knowledge. Heck, some quantum interactions are already (so far) computationally intractable, which is why quantum chemistry exists as a field at all, it's far from trivial. That doesn't mean the best practices developed for medicine won't help in the social sciences as well.

The issue with degrees of freedom can be mostly pinned down with preregistration, among other measures. It won't solve the problem of having more type I errors at any specific error rate the more science you do, but it does give assurances the target type I error rate is accurate.