[roenxi]

I was about to post a very similar comment. That last section elevates the article from "interesting" to "wow, that was great". It isn't just revealed wisdom; the gentleman want to show the limits of the knowledge.

And the "in silico" experiments are probably a bit of a sleeper for people outside the field. It is really obvious how improvements in computing power will have/had a transformative impact on this field. To go from poking out random molecules and growing dangerous things in a pitri dish to fast computer simulations from DNA seems like quite a big jump in how quickly the field can learn.