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by pfisherman 823 days ago
Epigenetics is not just DNA, think of it more like the (hidden) state of DNA. Histone modifications and open chromatin and other epigenetic readouts are like emissions / indicators of the hidden state.

The relationship is like that between the words in a book and the page that is actively being read. I know that is a hackneyed analogy; but coffee is wearing off :)

1 comments

Those are all readable using standard DNA sequencing techniques, so again, it's just state attributes of the DNA.

(I've worked in genomics for 30+ years. I'm not just spitballing here).

DNA libraries are read out using sequencing techniques. But I doubt anyone would say they are just measuring DNA. It’s kind of like saying a luciferase based assay is just measuring the intensity of light.
yes, that is the terminology we use.