There are exactly 2 websites where I feel like I need to increase my front size, HN (140%, no less) and old.reddit.com. Every other website I use looks fine.
And I'm not changing the font size on every website I visit for the rest of my life just so that HN can display properly at 100% zoom.
Then something in your setup is wrong. How many pixels your screen has is irrelevant, as long as your setup isn't broken CSS pixels should be (roughly) the same physical size.
And I'm not changing the font size on every website I visit for the rest of my life just so that HN can display properly at 100% zoom.