[derefr]

They sort of tried this in the '90s — not in the form of suppressing the required enzymes for nutrient absorption, but rather in the form of diet foods that contained inherently non-absorbable nutrients. The downsides were basically the same — the non-absorbed nutrients had to come out. People didn't generally respond well to these products. See e.g. https://web.archive.org/web/20060113084223/http://www.zug.co...

[vrc]

Olestra! I ate a whole bag of the Lay’s with Olean as a kid. They had the audacity to say that they assumed that people would only eat a handful at a time. Of near zero calorie potato chips that taste like potato chips…