[dekhn]

Realistically, we can't reduce false positives to absolutely zero without giving up on some True Positives (sensitivity/specificity tradeoff).

Nature intentionally plays loose with potentially world-changing discoveries. It probably makes sense to have some journals that publish with fairly high rates of (post-hoc determined) false positives, simply to move the fields forward more quickly.

[dudeinjapan]

Extraordinary claims require extraordinary evidence (and validation!)