Men can easily have childrens on their 40s (not recommended though, it's hard work) but women cannot. It's sad to see that most intelligent, talented woman fall in the trap of their careers and die childless. If you are an intelligent entrepeneur woman in their 20's, do yourself a favor, stop to have some childrens and then resume your career.
How can you know about the tradeoff? you remember your past lifes? nobody can, you will have to guess and often you will guess wrong. That's why very few people has great family planning skills at their 20's.