On accessibility: I see more custom components that nobody cares to make it properly working with keyboard interaction compared to native HTML input components.
On standards - mixed feelings: we had XHTML, now we don’t. We had IE and jQuery to deal with it, now we don’t need it, but I still see many places that have the old “works best with” message, now with Chrome instead.
On maintainable code: it’s a different shit show, we exchanged spaghetti code for billions of npm dependencies that break if you dare to try and upgrade something.