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by Footkerchief 846 days ago
The evidence we have for safety of low-level consumption doesn't look great.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691614/

"The paucity of adequate studies, particularly related to long‐term use of A. muricata supplements, currently does not allow the establishment of a safe intake level."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092620/

"Cognitive performance assessed with the MDRS worsens above a cumulative consumption threshold of 0.2 fruit‐years of Annonaceae fruit/juice (ie, one fruit every 5 days for 1 year) or with consumption of any quantity of Annonaceae herbal tea."

3 comments

"one fruit every 5 days for 1 year" is far above what I would consider occasional consumption.

Pawpaws are not in season for very long, and do not keep well. Unless you are canning or otherwise preserving them, a dozen per year is probably a high estimate for people who live in areas where they grow.

Relatives such as the soursop are available year-round in tropical areas, but if you limit your intake to the pawpaw only, eating a handful when they are ripe each year probably won't hurt you.

I lived in Maryland near a forest with a large number of wild pawpaw trees that produced an enormous amount of fruit, and was very into foraging as a hobby, and I don't think I ever ate more than six or seven in a single season.

The bark and leaves are the primary sources of benzyltetrahydroisoquinolines.
This study is of a small island population.