Code testing is a big one for me. I'm currently using in-memory sqlite for tests and I'm often running into differences between sqlite and postgres (default values, JSON handling, etc). This could allow me to use the real thing without running a full Docker instance.
I think performance and cost are the big motivators here.
I work on a web framework for building data apps like reports and dashboards, and we use duckDB’s WASM runtime for interactions (e.g when a user changes a date range filter). It’s really fast, and you don’t spend snowflake credits.