[neonsunset]

The .NET Framework target might as well not exist :D

Many libraries are straight up dropping NS2.0 TFM and overall community tends to perceive the request to still target it very negatively. Sure, Visual Studio still runs some in-process features on top of it, and so do Office add-ins, but it's an active work-in-progress to get rid of any new code having to be written while still targeting it.

So, in that regard, this setting does not matter.

[gfody]

in .net core there's no setting, you target the x32 abi by choosing a runtime or target platform ending in "32" or "x86"