What if it was a truly addictive, habit-forming, tolerance-building drug consumed on a habitual basis without ever allowing a full day, week, month, or year of detoxification to occur, regardless of its toxic properties?
>A necessary component of addiction as a disease is harm.
That really widens the basket.
In a case like this I tend to focus on toxiciity alone, whether it is apparent or not, that is one of the known things that can creep up on you and do irreparable damage.