[emsy]

You can’t compile on it. You can’t run software in the background (for example a terminal, where you don’t have to bring the app to the foreground every few minutes). You can’t install software on it that Apple doesn’t want you to (regardless of whether or not they’re malicious). And the software you can run is more likely than not a subscription, because the only place you can buy it is the App Store, which pushes the subscription model unto users and devs.

[deergomoo]

You also can't run servers which writes off huge parts of web development.