My boss likes to say "wow you must be drinking some strong stuff on the weekends after this job." Because apparently that's the ideal way to cope with abusive workloads.
He's not far off since you do cope with a depressant drug, just a different one with a different risk profile. And I don't know about you, but it tanks my productivity worse than alcohol all the way through the next day depending on the form. So maybe he's making a comment about that.