This is why I do it. To make my local dev system a bit closer to my (typically linux) deployment systems.
(I remember wasting a lot of time once on a rookie mistake where I had a Perl script with "use Strict;" in it instead of "use strict;", it worked fine on Mac OS (OS9, in this case), but failed in at-the-time-inexplicable ways when deployed on unix. I suspect my habig of insisting on choosing case-sensitive filesystem stems largely from that… And yeah, doing perl/cgi webdev on Mac OS9 was a really bad idea, I discovered.)
(I remember wasting a lot of time once on a rookie mistake where I had a Perl script with "use Strict;" in it instead of "use strict;", it worked fine on Mac OS (OS9, in this case), but failed in at-the-time-inexplicable ways when deployed on unix. I suspect my habig of insisting on choosing case-sensitive filesystem stems largely from that… And yeah, doing perl/cgi webdev on Mac OS9 was a really bad idea, I discovered.)