[ekianjo]

progress is measured by:

- identifying mechanism of action

- identifying therapeutic levers

- testing drugs and ahow that they can do something

we are not even at the first step with these biomarkers. observational studies are super noisy

[zamfi]

How can you identify a mechanism of action if you don't have any idea of what the possible agents are? Don't you first have to identify some of the molecules that may be involved, before you figure out which ones are causal and how that causality plays out?

That seems to be the point of this paper.