[greazy]

Nearly everything in this space is OSS. From the aligners to the assembly and the databases.

Last I checked 23andMe didn't perform whole genome sequencing but looked at some number of point mutations. It depends on what information you want. Eg for the sake of interest of actional genomics data.

[mfld]

While it's true that most of the tools for genomics are OSS, there is some good software and in particular some databases that are commercial and quite pricey.

And the sequencing machines and chemicals also don't come cheap, as the market has long been dominated by one vendor.