Sure, if you don't offer pagination or only have small tables, you can get away with offsets. I tend to go for cursors as a default because I like to build applications with performance in mind and it’s the same effort.
We may be talking about different things. I thought you were referring specifically to [database cursors](https://en.wikipedia.org/wiki/Cursor_(databases)) so that's what I was talking about. If you're talking about something else, like the concept of so-called "cursor-based pagination" in general, then that is still an option even with even randomly-generated primary keys, so long as there are other attributes that can be used to establish an order (which attributes need not be visible to the a user)
I have offered pagination over large tables, without database cursors or non-random keys, without offsets, while keeping performance in mind, with little effort.