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by genomer 872 days ago
The Nanopore Minion is still a thing, but it's sequencing and has higher error rates than competing short-read methods like Illumina's sequence by synthesis.

https://nanoporetech.com/products/sequence/minion

Sequencing DNA with nanopores: Troubles and biases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486125/

Based on what I'm seeing from 23andMe's website they only do genotyping, not sequencing.

https://customercare.23andme.com/hc/en-us/articles/227968028...

"23andMe uses genotyping, not sequencing, to analyze your DNA. Sequencing technology has not yet progressed to the point where it is feasible to sequence an entire person’s genome quickly and cheaply enough to keep costs down for consumers. It took the Human Genome Project, a consortium of multiple research labs, over 10 years to sequence the whole genomes of just a few individuals."

Edit: https://www.23andme.com/total-health

I guess they started providing whole exome sequencing, but I can't find information about what depth they're doing it at.

1 comments

Sure I don't need a full sequence, just the bits used for health features on 23andme.

Of course the closer to a full sequence the better as any future research could be used by just reading existing data. But realistically just having data on few hundred most useful markers is enough.