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by M95D 879 days ago
Software could, but hardware probably won't.

These kinds of computers usually have customized ISA boards that aren't even PnP compatible. Software for that kind of hardware doesn't use drivers. Hardware is directly accessed from software, like you would do on a bare-metal microcontroller. Modern OSs like Linux and anything WinNT/2000/+ won't allow this, but Win311 in real mode does.