Everything I've tried to get running, worked quite smoothly.
Although I only tried LLMs via llama-cpp and stable diffusion via ComfyUI.
I don't see any reason why other AI stuff wouldn't work as long as it supports rocm.
Also I only tried it on linux, AFAIK windows is a lot more difficult to get running, if it works at all...
With llama-cpp, I successfully tried various LLMs(e.g. LLAMA 13B, Mixtral etc) with very solid performance. Even for models that don't fit in VRAM completely, performance can be surprisingly solid, as long as you compile with AVX extensions. (and your CPU supports those)
Stable Diffusion via ComfyUI also works very well. However, be aware of VRAM limitations with the larger SDXL variants, especially when running a heavy desktop environment.
Regarding setup guides/links, there isn't a good centralized resource sadly, so some tinkering is needed. Unlike some of those CUDA 1-click solutions, ROCm requires more manual setup, especially for the models only unofficially supported.