[analog31]

That's certainly one use case. I might be the exception, trying to look up something on my phone, or following a link in a blog or HN post. Stuff in PDF's is hard to read, especially two column journal articles. I'm often not at my desk, since I might be in a meeting or in the lab.

[bowsamic]

Don’t you have a computer in your lab? Also I actually think the 2 column format works well on phone bc you can zoom in to fit the column to the screen

[analog31]

A computer at every lab bench, usually tied to specific experiments. Sometimes I sit down at an adjacent server and read something, sometimes pull out my phone.

Anything can be accommodated. One thought is to provide the source code, then people can adapt it to their display preferences. Like how HTML was originally envisioned.