[gilleain]

Thermal stability, as far as I know. So hyperthermophiles, presumably.

edit: hmmm. from this interesting review - https://www.sciencedirect.com/science/article/pii/S0959440X2... (open article) - it looks like some knots might increase mechanical stability and resitance to proteolysis

[dekhn]

Oh, cool- they turned a not-truly-a-knot (open ends) protein into a truly knotted one (connected ends) and then unfolded it using urea and it stayed knotted. That's what you'd expect but it's also pretty cool.