[mrphoebs]

The profound number of changes are in tact only if those changes aid in the natural selection of the organism against selection pressure.

Such changes are replicated more successfully (more offspring) making the change/mutation more resilient to disappearing from the genepool.

Over time any organism that's living/thriving is going to have a lot of these mutations stacked on top of one another in a resilient way(size of population with the same mutations). Any mutations that are disadvantageous to natural selection and proliferation are weeded out of the genepool (go extinct)