I treat the self-checkout as if it has the "10 items or less" sign for an express checkout some supermarkets used to have. If I need multiple bags, it's probably not faster to use the self checkout.
My bane back when I was a cashier and to this day thanks to self checkouts: weird shaped items that, while having a barcode, mean they'll never ever scan correctly. Powerade bottles were the worst for this, with the label going over a bunch of ridges in the bottle which made the label undulate like } and it was hopeless to try to scan the damn thing.