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My recommendation would be Duplicacy [0]. Code is also on GitHub [1].

It has a paid GUI version, $20 for the first year and $5 for subsequent years with discounts for multiple machines [2]. At least once they've run a promotion for a very cheap lifetime license.

Use it just from the CLI is free.

My setup is pretty simple, Syncthing and Duplicacy (GUI version) run in a docker container on my home server. Everything gets sync'd to the server and then Duplicacy backs it up hourly to a Hetzner Storage Box and BackBlaze B2.

The deduplication is a huge data saver on the cloud storage especially for pictures or videos that may be on multiple computers and different syncthing folders.

[0] https://duplicacy.com/ [1] https://github.com/gilbertchen/duplicacy [2] https://duplicacy.com/buy.html