[i8comments]

Metformin is a pretty nasty drug with some serious side effects on healthy people that is not proven to extend lifespan or healthspan in healthy people, and in fact makes you weak when taking it.

In fact, in 2024, it can be said it failed to live up to its hype.

Only take it if you have diabetes.

[prepend]

What nasty side effects do you mean?

There’s really almost none [0] with the most common diarrhea.

[0] https://en.wikipedia.org/wiki/Metformin

[sithadmin]

Not sure it qualifies as “nasty”, but performing does seem to somewhat impede expected benefits from exercise: https://peterattiamd.com/metformin-and-exercise-deja-vu-all-...

It also seems to upregulate cortisol in some cases, which is undesirable: https://pubmed.ncbi.nlm.nih.gov/27459533/

[prepend]

These definitely don’t seem very nasty to me. I suppose it’s good to be aware of these effects, but don’t imagine them affecting most people’s decision to take it unless they are bodybuilders or something.