I think you are forgetting prescription drugs, who have had their dangers grossly underestimated to further medical industry profits.
Every day I see people on the streets, destroyed and turned to ghouls in great part because of the well known destructive drugs. Heroin, crack cocaine, meth, alcohol. There is no reason to pretend these aren't destructive. And there is no reason to put psychedelics in the same category, because these substances have nothing in common.
Each American needs to be given the facts and then decide for themselves, just like with religion.