That's kinda how we've approached it with some of the IndieWeb tools (https://indieweb.org/reader) where you can subscribe to the various feeds you want to, and can directly like/reply/etc
I am an active user of Monocle (https://monocle.p3k.io), a social reader UI (which is connected to a feed polling service, in my case Aperture). I can click "like" or "reply" and the reaction is published on my personal website. A notification is sent to the recipient via Webmention that I liked/commented on their content (if their site supports webmention).